Folic acid and prevention of neural-tube defects.
نویسندگان
چکیده
QUESTION Now that flour and pasta have been fortified with folic acid in Canada, do I still need to recommend folic acid supplements to my patients who are of child-bearing age? If I should recommend supplements, when should I recommend them, and what is an appropriate dose? ANSWER Non-pregnant women should consume 400 microg of folic acid daily, and pregnant women should consume 600 microg of folic acid daily. Mean intakes of folate in Canada before fortification were around 200 microg/d or less. Fortification increased intake of folic acid by up to 100 microg/d. You should discuss the importance of folic acid with your patients who are planning pregnancy; it is recommended that a folic acid supplement or prenatal multivitamin containing at least 400 microg of folic acid be consumed daily. The upper limit for folic acid is 1 mg/d. Women in intermediate- to high-risk categories for neural tube defects, such as a previous neural tube defect-affected pregnancy, should take 4 to 5 mg of folic acid daily.
منابع مشابه
I-8: Folic Acid and Female Fertility in Natural and Assisted Reproduction
Background Pre-conceptional supplementation with folic acid is recognized as essential for the prevention of neural tube defects. However, the reproductive effects of folic acid may extend well beyond this well-recognized effect and may have an important role in improving fertility and survival of the conceptus and fetus. MaterialsAndMethods We evaluated the association between pre-conceptional...
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Introduction & Objective: Folic acid a member of vitamin B complex has an important role in prevention of neural tube defects. The closure of neural folds occurs at 28th day of pregnancy and most of women are not informed about their pregnancy at this time, so folic acid supplementation must begin before pregnancy. This study conducted with the aim of determining preconception intake of folic a...
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BACKGROUND Neural tube defects are among the most common birth defects, contributing to miscarriage, infant mortality, severe congenital abnormalities and serious disabilities. It is burdensome to patients, caregivers, healthcare systems and society. It could be reduced if women consume a folic acid supplement before and during the early weeks of pregnancy. This study assesses folic acid usage ...
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متن کامل
بررسی میزان نقایص لوله عصبی و فاکتورهای موثر در بروز آن در زمان لقاح در زنان باردار
Introduction & Objective: After cardiac defects, neural–tube defects (NTD) are the most congenital structural defects with a worldwide incidence of 1.4 to 2 per 1000 live births. This defect is due to failure of the neural tube to close spontaneously between the 3rd and 4th wk of uterine development. The control of risk factors related to NTD, decreases the psychologic problems and it is cos...
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ورودعنوان ژورنال:
- Lancet
دوره 350 9078 شماره
صفحات -
تاریخ انتشار 1992